Membrane proteins in cell-cell communication: architecture and mechanisms

Extracellular signaling plays a central role in cell-cell communication for all multicellular organisms, orchestrating various life processes from body formation to brain function. This diverse and important signaling is exquisitely controlled by a variety of membrane proteins.

We investigate how these dynamic and fine-tuned proteins are built, how they release/receive signals, and how they integrate and convey these signals across the cell membrane.